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Vitiligo symposium, ESPCR Barcelona

Source: www.espcr.org
Topic: Vitiligo
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Sort Desciption: symposium which completed the vitiligo session of the plenary meeting. ... association with sun exposure in vitiligo, a technique felt generally difficult to ...

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Vitiligo Symposium ESPCR Meeting Barcelona sep 2006 by Prof. Alain Taeb Several contributions were presented in a « from bench to bedside » approach in this symposium which completed the vitiligo session of the plenary meeting. The bench side was illustrated by Cario-Andr et al (Bordeaux) who showed data testing the melanocytorrhagic hypothesis on epidermal reconstructs with melanocytes. Several tested agents were able to trigger the detachment of melanocytes, especially decomplemented sera from some patients. It was also shown that vitiligo melanocytes have an intrinsic defect which limits their adhesion in a reconstructed epidermis, with an enhancer effect of the vitiligo keratinocyte milieu. DellAnna et al (Rome) presented new data suggesting that a compromised melanocyte membrane could render the cell sensitive to the external and internal agents differently, usually ineffective on the cell activity and survival. The primitive altered arrangement of the lipids may affect the transmembrane housing of proteins with enzymatic or receptorial activities, also conferring on them antigenic properties. C Le Poole (data presented by A Overbeck, Madrid) made observations suggesting a disturbance of regulatory T cells in vitiligo patches. On the bedside aspects, A Alomar (Barcelona) made a strong point to rehabilitate the use of khellin in association with sun exposure in vitiligo, a technique felt generally difficult to handle by other clinicians. A Fongers (Amsterdam) reported on the long term results of the minigrafting technique which is now less used with the development of autologous ultrathin grafts and cell suspension grafting. Y Gauthier (Bordeaux) reviewed a large series 130 segmental vitiligo (SV) patients with facial involvement showing that SV did not follow exactly dermatomes and was frequently overlapping one, two or three dermatomes. In some cases SV developed in areas supplied by nerves damaged in an injury, ...

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