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Loss of melanocytes in epidermis affected by vitiligo

Source: www-ermm.cbcu.cam.ac.uk
Topic: Vitiligo
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Sort Desciption: Melanocytes in a sheet of normal epidermis shown by dihydroxyphenylalanine (DOPA) staining, which detects the activity of the melanogenic enzyme tyrosinase present in melanocytes. Appearance of an epidermal sheet from a patient who has vitiligo, after staining with DOPA, showing a much reduced melanocyte density. ...

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Loss of melanocytes in epidermis affected by vitiligo 1 expert reviews in molecular medicine Figure 1. Loss of melanocytes in epidermis affected by vitiligo. (a) Melanocytes in a sheet of normal epidermis shown by dihydroxyphenylalanine (DOPA) staining, which detects the activity of the melanogenic enzyme tyrosinase present in melanocytes. (b) Appearance of an epidermal sheet from a patient who has vitiligo, after staining with DOPA, showing a much reduced melanocyte density. Images courtesy of Dr D.J. Gawkrodger, Department of Dermatology, Royal Hallamshire Hospital, Sheffield, UK (fig001hks) . Melanocytes in normal epidermis (DOPA staining) Loss of melanocytes in an epidermis that is affected by vitiligo (DOPA staining) 100 m b a Loss of melanocytes in epidermis affected by vitiligo 100 m Expert Reviews in Molecular Medicine 2001 Cambridge University Press

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Total 1 Comment

#01

by: Ashraf
05 May 2008 01:09 AM
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here I want ot share some deep knowledge about above description The expert discovered that NALP1 a gene that controls part of the immune system that serves to alert the body to viral and bacterial attacks was a key gene involved in predisposing to vitiligo and all the other autoimmune diseases that ran in these families. Resources: http://www.antivitiligo.com http://www.medicalnewstoday.com/articles/65881.php "The findings give us a clue to why the immune system attacks one of the body's own tissues: if the sensor NALP1 is over-reactive, it could trigger a response to the wrong stimulus

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