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International Symposium on Vitiligo

Source: www.vitiligosociety.org.uk
Topic: Vitiligo
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Sort Desciption: Vitiligo from Gene to Clinic: New Insights in Research and Treatment ... Vitiligo 1,2 is a condition of unconfirmed aetiology, but with behaviour and reasonable investigative evidence suggesting it is most likely a genetically based autoimmune disorder with melanocyte antigen as the primary target ...

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Vitiligo 1,2 is a condition of unconfirmed aetiology, but with behaviour and reasonable investigative evidence suggesting it is most likely a genetically based autoimmune disorder with melanocyte antigen as the primary target; the severity of the disorder is then apparently determined by the degree of genetic susceptibility and continuing local, usually minor, cutaneous trauma. Some atypical forms do not however appear immunologically based, while psychological factors may perhaps also play a part in precipitating or worsening the condition in occasional subjects. Probably about 1-2% of the population worldwide of any race and either sex appear susceptible, and the disorder may begin at any age, but most commonly in the second or third decade of life, typically demonstrating slowly or rapidly appearing and enlarging hypopigmented skin macules, occasionally also with loss of contained hair colour or minimal textural change. They may be single or multiple, affect any site, be gradually joined by more macules over months to years, often with inactivity superseded by progression, though occasional cases remit. Affected body sites are commonly symmetrical, and often subject to minor trauma such as eyelids, axillae, elbows, backs of hands, knees, genital area, lips and nipples. Lesions are frequently of geographical shape and sharply demarcated from surrounding skin, but may be single, ill-defined, on any body site or asymmetrically located, while stable, usually early onset, segmental forms also exist; after many years, or rarely rapidly, widespread vitiligo may develop, rarely affecting virtually the whole body surface. ...

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