Seborrheic Dermatitis in Patients with Acquired Immunodeficiency ...
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Topic: Seborrheic
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Sort Desciption: Several skin conditions are known to be associated with the acquired immune deficiency syndrome (AIDS). Our clinical observations suggested the hypothesis that seborrheic dermatitis is an ...
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Several skin conditions are known to be associated with the acquired immune deficiency syndrome (AIDS). Our clinical observations suggested the hypothesis that seborrheic dermatitis is an under-recognized but common skin manifestation of AIDS that has important, short-term prognostic significance.
All patients with AIDS seen at the Henry Ford Hospital, an urban hospital, during a one-year period were enrolled in a cohort study. Each patient underwent a comprehensive skin examination. All skin conditions were noted, and the severity of seborrheic dermatitis was graded. A group of sex and aged matched patients seen during the same time period served as a control group. In the second part of the study, AIDS or HIV patients with the most severe grades of seborrheic dermatitis were compared to patients with mild or no seborrheic dermatitis for short term mortality. Comparisons were analyzed with chisquare and relative risk calculations.
Eighteen patients with AIDS and 12 patients with HIV infection were enrolled (29 males, 1 female). Thirty age and sex matched controls were randomly selected from the patient roster. The most common risk factors for the cases were homosexuality and IV drug abuse. Eighty percent (15/18) of AIDS- and 42% (5/12) of HIV-infected patients had seborrheic dermatitis compared 10% (3/10) of controls (P <0.001 AIDS vs. controls, P =0.07 for HIV patients vs. controls, and P = 0.01 for AIDS- vs. HIV-infected). The severity of seborrheic dermatitis seemed to be associated with short-term prognosis. Of the 6 patients who died during the study, 3 developed severe seborrheic dermatitis within six months and 2 developed moderate seborrheic dermatitis within a year of their deaths (relative risk = 2.5, 95% CI = 1.9â 3.3). Of the 5 HIV infected patients with seborrheic dermatitis, 2 with moderate grade progressed to AIDS and one subsequently died during the study period.
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