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Absence of Human Papillomavirus DNA in Nongenital Seborrheic Keratosis

Source: jkms.kams.or.kr
Topic: Seborrheic
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Sort Desciption: Human papillomavirus (HPV) has been detected in various benign or malignant epidermal tumors (1-5). Seborrheic keratoses (SK), which are benign epidermal tumors, are similar ...

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Human papillomavirus (HPV) has been detected in various benign or malignant epidermal tumors (1-5). Seborrheic keratoses (SK), which are benign epidermal tumors, are similar and often confused with warts in their clinical and/ or histological appearance. These similarities have led investigators to study the role of HPV in the pathogenesis of seborrheic keratoses (6-10). Zhao et al. (6) detected, by electron microscopy, HPVlike particles in 4 of 89 nongenital SK. In cases of seborrheic keratoses of cases of the genital area, HPV has been reportedly found in 42% (n=57) using polymerase chain reaction (PCR) from tissue extracts (7). However, the same group reported lack of HPV-DNA in nongenital SK (8), demonstrated by PCR from tissue extracts (n=27). Soler et al. (9) showed HPV type 5 DNA by in situ hybridization in a nongenital SK obtained from a renal transplant recipient. Recently, Tsambaos et al. (10) detected HPV-DNA in 20% (34/173) of nongenital SK specimens using in situ hybridization. We believe that it is necessary to clarify the discrepancies of HPV-DNA detection in nongenital SK using accurate and sensitive methods. To demonstrate the presence of HPV in nongenital SK, we analyzed 40 biopsy specimens taken from patients with nongenital SK using in situ PCR and PCR from tissue extracts. MATERIALS AND METHODS To investigate the possibility that HPV might be a causative factor for SK, ...

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