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THE ROLE OF DUST MITES IN ATOPIC DERMATITIS:

Source: nyallergy.com
Topic: Dermatitis
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Sort Desciption: The ubiquity and the allergenicity of the dust mite makes it suspect as another trigger for exacerbations of the eczematous twitchy skin of atopics. ...

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The ubiquity and the allergenicity of the dust mite makes it suspect as another trigger for exacerbations of the eczematous twitchy skin of atopics. The golden standard for contact allergens is the patch test; thus, the Eczema Committee of the American Academy of Allergy and Immunology decided on a protocol for patch testing with dust mite allergen, to be tested at six different sites, to evaluate the role of dust mites in atopic dermatitis. The rationale and preliminary impressions of this project are presented. Atopic dermatitis (AD) is well recognized as the third component of the atopic triad. Although the role of allergens as triggers for asthma and rhinitis is universally accepted, their role in AD remains a source of contention. This controversy may be due to the relative ease of identifying the secretagogue of IgE/mast-cell-induced immunologic reactions of respiratory allergy, and the less precise identification of the triggers of T-cell-induced immunologic reactions believed to produce eczema. A solution for the confusion may be the recent elucidation that many clinical syndromes are not restricted to a single Gell and Coombs immunologic response, but that they may be the result of an intricate interplay of several or all the immunologic responses. Immunologic responses are the result of activation of the varied receptors on mast cells and T cells and the release of their respective inflammatory mediators. Dust mites, pets, and pollens are common triggers (type I IgE/mast-cell-mediated) of respiratory allergies, but their pathoetiologic role in AD is often questioned; however, recent evidence suggests that AD may represent the paradigm of an IgE-mediated T-cell ...

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