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Successful treatment of severe atopic dermatitis with cysteinyl leukotriene

Source: www.mf.uni-lj.si
Topic: Dermatitis
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Sort Desciption: Experimental data suggest a role for cysteinyl leukotrienes in the pathogenesis of atopic dermatitis and there is a rationale for the use of pharmacological agents to antagonize their effects in the treatment of atopic dermatitis. ...

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Experimental data suggest a role for cysteinyl leukotrienes in the pathogenesis of atopic dermatitis and there is a rationale for the use of pharmacological agents to antagonize their effects in the treatment of atopic dermatitis. We report 2 cases of severe atopic dermatitis successfully treated with montelukast as a single therapeutic agent in a daily dose of 10 mg for 8 weeks when corticosteroid treatment was contraindicated or failed to control the disease. Our observations suggest that montelukast may be used as an alternative steroid sparing medication for severe atopic dermatitis, especially in patients with associated asthma and rhinitis. atopic dermatitis, steroid sparing treatment, cysteinyl leukotriene receptor antagonists, montelukast K E Y W O R D S C a s e r e p o r t Montelukast in atopic dermatitis S U M M A R Y *montelukast Singulair tablets,, MSD Introduction Cysteinyl leukotrienes (CysLTs) are potent proinflammatory mediators derived from arachidonic acid through the 5-lipoxygenase pathway. They exert pharmacological effects by interaction with at least two different receptors, the CysLT1 and CysLT 2. There is evidence that the pathobiologic phenomena underlying the manifestations of atopy-related asthma and rhinitis are mediated by the cysteinyl leukotriene 1 receptor subtype. By competitive binding to the CysLT1 receptor, leukotriene receptor antagonists (LTRAs) block the effects of cysteinyl leukotrienes and alleviate the symptoms of asthma and allergic rhinitis. Because of the common association of atopic dermatitis (AD) with allergic asthma and rhinitis, improvement ...

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