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Lipid kinetic differences between children with kwashiorkor and those ...

Source: www.ajcn.org
Topic: Kwashiorkor
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Sort Desciption: with poor prognosis in kwashiorkor, but not in marasmus, is im ... ished children with kwashiorkor or marasmus. ... kwashiorkor, the breakdown of muscle ...

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It has been hypothesized that one factor associated with poor prognosis in kwashiorkor, but not in marasmus, is impaired lipid catabolism, which limits the supply of energy that is essential for survival when dietary intake is inadequate. However, this hypothesis has not been tested. Objective: The objective was to measure lipid kinetics in malnourished children with kwashiorkor or marasmus. Design: Glycerol concentration and flux (index of total lipolysis), palmitate concentration and flux (index of net lipolysis), and palmitate oxidation rate (index of fatty acid oxidation) were measured in 8 children (n 5 boys and 3 girls) with kwashiorkor and 7 (n 4 boys and 3 girls) with marasmus, aged 4 20 mo, in the postabsorptive state. The measurements were made 3 d after admission, when the children were malnourished, and after the children attained normal weight-for-length, ie, at recovery. Results: The glycerol concentration was higher in the malnourished stage than at recovery for the marasmus and kwashiorkor groups combined. Glycerol flux tended to be lower (P 0.067) and palmitate flux significantly lower (P 0.05) in the kwashiorkor group than in the marasmus group. Palmitate oxidation was significantly lower in the ...

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