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Management of Primary Biliary Cirrhosis

Source: www.aasld.org
Topic: Cirrhosis
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Sort Desciption: AASLD Practice Guidelines Management of Primary Biliary Cirrhosis E. JENNY HEATHCOTE Primary biliary cirrhosis (PBC) is apresumedautoim- munediseaseofthe liver, which ...

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Primary biliary cirrhosis (PBC) is apresumedautoim munediseaseofthe liver, which predominantly affects women once over the age of 20 years. Most cases are diagnosed when asymptomatic (60%). The antimitochon drialantibodyis present in serum inmost, but not in all, patients withPBC. The disease generally progresses slowly but survival is less than an age-and gender-matched general population. The symptomatic patient may have fatigue, generalized pruritus, portal hypertension, osteoporosis, skin xanthomata, fat soluble vitamin deficiencies, and/or recurrent asymptomatic urinary tract infections. ...

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