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Resolution of Chronic Hepatitis B-Associated Autoimmune Neutropenia ...

Source: www.hepatitis.cl
Topic: Autoimmune hepatitis
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Sort Desciption: Chronic hepatitis B virus (HBV) is one of the most prevalent viral infections, affecting at least 1 million people in the United States and 300 million people worldwide ...

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Chronic hepatitis B virus (HBV) is one of the most prevalent viral infections, affecting at least 1 million people in the United States and 300 million people worldwide (1). Although cirrhosis and hepatocellular carcinoma are the most important complications of chronic HBV infection, extrahepatic manifestations also occur, including immune-mediated diseases such as polyarteritis nodosa (2), cryoglobulinemia (3), and membranous glomerulopathy (4). Although uncommon, these extrahepatic manifestations can cause significant morbidity and mortality. The recognition of these HBV complications is important because management of the underlying viral infection may result in resolution of the extrahepatic manifestations. We report a case of autoimmune neutropenia associated with chronic HBV and its response to interferon(IFN) therapy. CASE REPORT The patient was a Korean-born child who was adopted when aged 5 months by US parents. Her serum test results at 11 months were positive for hepatitis B surface antigen (HBsAg). There was no information on the status of her biologic parents, but her adoptive parents test results were negative for HBsAg and antibody (antiHBs). She was referred to the Clinical Center of the National Institutes of Health (NIH) for evaluation and treatment when aged 15 months. When first examined, she had no history of jaundice, dark urine, bruising, abdominal swelling, gastrointestinal bleeding, severe infections, or allergies. An atrial septal defect was diagnosed shortly after birth, ...

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