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Guidelines for Therapy of Autoimmune Liver Disease

Source: www.higadocolombia.org
Topic: Autoimmune hepatitis
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Sort Desciption: The principle of therapy for chronic inammatory liver diseases is the removal of causal agents. For autoimmune liver diseases, however, total removal of causal agents and immune cells is impossible. ...

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The principle of therapy for chronic inammatory liver diseases is the removal of causal agents. For autoimmune liver diseases, however, total removal of causal agents and immune cells is impossible. Therefore, autoimmune liver diseases are presently treated by suppression of the immune response. Autoimmune hepatitis is characteristically responsive to corticosteroids, often used in combination with azathioprine to obtain a steroidsparing effect. For primary biliary cirrhosis, ursodeoxycholic acid is safe and is the rst choice for treatment. Treatment of this autoimmune liver disease should also address various symptoms and complications arising from any associated autoimmune diseases, particularly cholestasis and cirrhosis-related complications. For primary sclerosing cholangitis there are no established immunomodulatory therapies, but medical, endoscopic, and surgical treatments are applicable to this disease. Liver transplantation becomes indicated during the eventual end stages of each of these immune-mediated liver diseases. KEYWORDS: Treatment, guideline, autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, overlapping syndrome L iver damage can be caused by a variety of agents including biological, chemical, and physical factors. Continuous existence of these causal agents leads to the chronic inammation of the liver after the initial inammatory and immunological response. Therefore, the therapy for chronic inammatory liver diseases is removal of these causal agents. For chronic viral hepatitis such as hepatitis B and C, hepatitis viruses should be eliminated by antiviral agents such as nucleoside analogues for hepatitis B virus and interferon for hepatitis C virus. For drug-induced liver injury or alcohol-related liver ...

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