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Autoimmune Hepatitis Primary Biliary Cirrhosis Primary Sclerosing ...

Source: www2.niddk.nih.gov
Topic: Autoimmune hepatitis
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Sort Desciption: Autoimmune liver disease occurs when the body reacts inappropriately to its own cellular components and includes with autoimmune hepatitis such as plasma cells ...

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Autoimmune liver disease occurs when the body reacts inappropriately to its own cellular components and includes with autoimmune hepatitis such as plasma cells (see inset for closer view of plasma cells). cirrhosis shows a bile duct lesion. (ERCP) from a patient with primary sclerosing cholangitis hepatic bile ducts (arrow). autoimmune hepatitis, primary biliary cirrhosis, and primary sclerosing cholangitis. TOP: A liver biopsy from a patient shows inltration of immune cells Photo: Dr. Zachary Goodman, Division of Hepatic Pathology, Armed Forces Institute of Pathology. MIDDLE: A liver biopsy from a patient with primary biliary Photo: Dr. Zachary Goodman, Division of Hepatic Pathology, Armed Forces Institute of Pathology. BOTTOM: An endoscopic retro grade cholangiopancreatograph shows strictures in the extra Photo: Dr. Sandy Irani, George Washington University. CHAPTER 9: AUTOIMMUNE LIVER DISEASE INTRODUCTION AND BACKGROUND Autoimmune liver diseases include autoimmune hepatitis, primary biliary cirrhosis, and primary sclerosing cholangitis. All three diseases can be severe, progressive, and lead to cirrhosis and death from endstage liver disease. Because none of the currently available therapies are curative, these diseases remain important causes of liver failure requiring transplantation. Strikingly, these diseases recur in 10 to 30 percent of patients after liver transplantation. Autoimmune hepatitis affects approximately 17 persons per 100,000 population. Autoimmune hepati tis occurs most commonly in women, particularly during adolescence, but this disease can occur at any age, in both men and women, and in persons of any race or ethnicity. Autoimmune hepatitis often results in severe hepatitis that can rapidly progress to cirrhosis. Diagnosis is based upon clinical features, the ...

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