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Hormonal Therapy for Prostate Cancer: a Guide for Patients

Source: urology.ucsf.edu
Topic: Prostate
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Sort Desciption: against its use in various settings of prostate cancer treatment. ... treatment for advanced prostate cancer, appeared to exert a novel estrogenic effect, but was ...

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Hormonal Therapy for Prostate Cancer: a Guide for Patients Hormonal Therapy for Prostate Cancer: a Guide for Patients Matthew R. Cooperberg, MD, MPH and Peter R. Carroll, MD, FACS Department of Urology, UCSF/Mt Zion Comprehensive Cancer Center, University of California, San Francisco, CA, USA Note: This article has been condensed and adapted to lay language from a recently published scientific review, to which readers are referred for more information and full reference bibliography: Cooperberg MR, Small EJ, DAmico A, Carroll PR. The evolving role of androgen deprivation therapy in the management of prostate cancer. Minerva Urol Nefrol 55(4):219-38, 2003. Over sixty years ago, the Nobel Prize in Medicine was awarded to Charles Huggins and Clarence Hodges for their discovery that depriving the prostate gland of androgenstestosterone and other male sex hormonesleads to the death of both normal and cancerous prostate cells. Since that time, androgen deprivation therapy (ADT) has become a mainstay of treatment for prostate cancer. Prostate cancer may be conceptually divided into clinically localized cases, which are confined to the prostate and may be treated effectively with surgery, radiation, or other local treatments; and advanced disease, in which the cancer has spread beyond the prostate to lymph nodes, bones, or other sites. For advanced prostate cancers, ADT remains by far the gold standard treatment; for localized tumors, its appropriate role is in evolution. This ...

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