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Chapter 15: Screening for Pancreatic Cancer

Source: www.ahcpr.gov
Topic: Pancreas
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Sort Desciption: ... Boyle P, Hsieh C-C, Maisonneuve P, et al. Epidemiology of pancreas cancer (1988) ... radical resection of cancer of the pancreas with intraoperative radiotherapy. ...

Content Inside:
Burden of Suffering Cancer of the pancreas is the fifth leading cause of cancer deaths in the U.S., accounting for an estimated 27,000 deaths in 1995 (8.4 deaths/100,000 persons). 1,1a Worldwide, the age-adjusted incidence and mortality of pancreatic cancer have been increasing since the 1930s, 2,3 although in the U.S. these rates have declined since the early 1970s. 1,1a Incidence rates may be overestimated, because an important proportion of pancreatic cancer diagnoses (as many as half in some studies) are not histologically confirmed. 4 Pancreatic cancer is more common in men, blacks, cigarette smokers, and older persons (the majority of cases being diagnosed between ages 65 and 79). 1,2,3,5 The risk of pancreatic cancer is increased in patients with diabetes, including those with long-standing ( 5 years) diabetes. 5a Familial aggregations of pancreatic cancer are rare but have been described. 2,6 Since initial symptoms are usually nonspecific (e.g., abdominal pain and weight loss) and are frequently disregarded, some 8090% of patients have regional and distant metastases by the time they are diagnosed. 5,7 Only 3% of the 24,000 patients annually diagnosed with pancreatic cancer live more than 5 years after diagnosis. 1,1a Of pancreatic adenocarcinomas, which account for more than 90% of all pancreatic neoplasms, 5 only about 416% are resectable at diagnosis, 4,812 and the 5-year survival rate is less than 1%. 7 In ...

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