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Report of the Stomach/Esophageal Cancers Progress Review Group

Source: planning.cancer.gov
Topic: Esophagus
Download: Click here!

Sort Desciption: for gastric cancer, esophageal adenocarcinoma, and esophageal squamous ... esophagus are relatively easy and safe to. access, which can provide ample specimens ...

Content Inside:
Population Studies
Establish collaborations for conducting interdisciplinary, population-based, endoscopic, multi-institutional studies to identify populations at greatest risk for gastric cancer, esophageal adenocarcinoma, and esophageal squamous cancer, and to determine the prevalence and natural history of premalignant lesions.

Prevention
Develop prevention strategies based on the mechanisms of host/environment interactions that lead to metaplasia and neoplasia of the stomach and esophagus. Evaluate their effectiveness in at-risk populations.

Patient/Provider Education
Educate patients and their families, health care professionals, and the public regarding risk factors, risk reduction, and treatment options and outcomes for gastroesophageal cancers and their precursor states.

Therapy
Develop and test novel therapeutics, and optimize existing treatments for gastroesophageal cancers and their precursors, based on the identification and understanding of molecular pathways involved in oncogenesis, tumor response and resistance.

Therapeutic Targets
Define host and molecular/biologic tumor characteristics that will help customize treatment and best predict recurrence and/or survival.

Markers and Molecular Profiling
Profile the molecular, cellular, and epidemiological features of gastroesophageal tumors and their precursor lesions to identify diagnostic, prognostic, predictive, preventive, and therapeutic targets.

Outcomes
Develop and refine disease-specific, patient-oriented methods to assess quality of life, quality of care, and cost effectiveness of treatment in patients with gastroesophageal cancers and their precursors through all stages of disease and treatment, and include these instruments in clinical trials and observational studies.

Host/Environmental Interactions
Identify, develop, and validate genetic, biochemical, and biological markers that will help uncover host-environment interactions in esophageal and gastric carcinogenesis.
v Technologies for Screening/Surveillance
Develop noninvasive and minimally invasive technologies (e.g. serum markers and imaging techniques) for screening and surveillance of premalignant and malignant gastroesophageal lesions.

Preclinical Models
Establish models to understand the biology of gastroesophageal cancers and their precursor lesions, and to stimulate prevention, diagnostic and treatment strategies.

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