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Cutaneous Necrobiosis Tissue Reaction In Systemic Diseases

Source: www.geocities.com
Topic: Systemic Connective Tissue
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Sort Desciption: Necrobiosis is applied to certain granulomatous disorders where the dermal connective tissue becomes homogenized and loses its normal staining characteristics. ...

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Necrobiosis is applied to certain granulomatous disorders where the dermal connective tissue becomes homogenized and loses its normal staining characteristics. It is a pathological finding, which is observed not only in a simple localized skin lesion, e.g. granuloma annular (GA), necrobiosis lipoidica (NL), but also in skin lesions which associated with underlying systemic diseases. Aim of the work: to explore the possibility that, cases with underlying systemic disorders could exhibit distinctive cutaneous necrobiosis tissue reaction. Patients and methods: The study group comprised 11 patients (9 females and 2 men ranging in age from 19 to 63 years) in whom 16 skin biopsies yielded a histological picture of necrobiotic granuloma, and in whom a clinical history showed systemic disease. The main systemic disease associations were diabetes mellitus, rheumatoid arthritis, malignant nodular goiter, Wegners granulomatosis with highly positive. c-ANCA, primary nodal lymphoma and cutaneous granulomatous mycosis fungoides, Crohns disease, hepatitis C virus, systemic lupus erythematosus with lupus anticoagulant , and hyperthyroidism. The clinical and histopathological features were compared with those of a control group of patients (without systemic disease) in whom, skin biopsies showed necrobiosis and were diagnosed as GA or NL. Results: in systemic disease group, the biopsied lesions showed necrobiotic granuloma in association with other ...

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