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Connective Tissue Diseases

Source: www.utmb.edu
Topic: Systemic Connective Tissue
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Sort Desciption: The connective tissue diseases have a pattern of organ involvement that overlaps and often makes specific diagnosis difficult. When first recognized as a distinct histopathologic characteristic, ...

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The connective tissue diseases have a pattern of organ involvement that overlaps and often makes specific diagnosis difficult. When first recognized as a distinct histopathologic characteristic, the perivascular collagen deposition prompted the name collagen vascular disease. Their association with immunologic reactions to body proteins subsequently caused the name change to autoimmune diseases. These entities are, however, more correctly called connective tissue diseases. Biochemical and ultrastructure studies indicate that collagen derangement and evidence of autoimmunity may not be the primary disease. The exact cause of connective tissue diseases remains obscure. Specific autoantibodies are associated with some of these entities, supporting the presumption of an autoimmune mechanism. Definite evidence demonstrating loss of self-tolerance or specific antigens is lacking. The prevailing histopathologic feature of these diseases is a ...

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