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Soft Tissue Sarcomas - SEER Pediatric Monograph

Source: seer.cancer.gov
Topic: Soft Tissue
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Sort Desciption: Incidence The soft tissue sarcomas of children and adolescents arise primarily from the connective tissues of the body, such as fibrous tissue, adipose tissue, and muscle tissue. ...

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Incidence The soft tissue sarcomas of children and adolescents arise primarily from the connective tissues of the body, such as fibrous tissue, adipose tissue, and muscle tissue. The sarcomas that arise from bone are discussed separately in the bone tumor chapter. In the US, 850-900 children and adolescents younger than 20 years of age are diagnosed with soft tissue sarcomas each year, of which approximately 350 are rhabdomyosarcomas. The incidence of soft tissue sarcomas for children and adolescents younger than 20 years of age was 11.0 per million (Table IX.2), representing 7.4% of cancer cases for this age group. Rhabdomyosarcoma was the most common soft tissue sarcoma among children 0-14 years, representing nearly 50% of soft tissue sarcomas for this age range (Figure IX.1) with an incidence rate of 4.6 per million (Table IX.2). There are two major types of rhabdomyosarcoma: embryonal (about 75% of rhabdomyosarcoma cases) and alveolar. These two subtypes tended to occur at different body sites (Figure IX.3) and had different age patterns (Figure IX.2). The incidence of embryonal rhabdomyosarcoma was higher among children 0-4 years, while the incidence of alveolar rhabdomyosarcoma was similar throughout childhood (Figure IX.2). Other types of soft tissue sarcomas are rare and the incidence is higher in adolescents compared to younger children. Among these are the fibrosarcomas, malignant fibrous histiocytoma, synovial sarcoma, leiomyosarcoma, liposarcoma, and others (Table IX.2). For infants, the most common soft tissue sarcoma was embryonal rhabdomyosarcoma. However, a distinctive set of other soft tissue sarcomas can develop in infants (e.g., infantile fibrosarcoma and malignant hemangiopericytoma). These tumors are different from ...

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