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BONE, SOFT TISSUE, AND GASTROINTESTINAL STROMAL TUMORS

Source: www.cancercare.org
Topic: Soft Tissue
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Sort Desciption: A Report on the Latest Research and Treatments from ASCO the American Society of Clinical Oncology ...

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Gastrointestinal Stromal Tumor (GIST) For people with rare cancers of the upper intestinal tract called gastrointestinal stromal tumors (GISTs) , treatment options used to be limited. Chemotherapy rarely worked against the cancer, and radiation was not very effective either. It usually came down to surgical removal of the cancer. However, in 2002, researchers reported that a drug called imatinib (Gleevec) shrank tumors in about 50 percent of patients with GIST. Moreover, the tumors continued to grow in only about 15 percent of patients who used imatinib. The drug works by preventing substances called receptors from sending signals to cancer cells to grow and multiply. The ndings on imatinib had a tremendous impact on GIST treatment. The research was among the rst and most important demonstrations of a new class of drugs that target cancer cells primarily, while sparing healthy tissues and causing few side effects. The discovery energized the entire eld of cancer research. But although imatinib slows or stops cancer growth when people rst take it, after about two years more than half the patients become resistant to the drug. Researchers suspect ...

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