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Genetics and Paget's Disease of Bone

Source: www.niams.nih.gov
Topic: Paget's disease of bone
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Sort Desciption: Pagets disease of bone is a treatable chronic disease that results in enlarged and misshapen bones in one or more areas of the skeleton. ...

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What Is Pagets Disease of Bone? Pagets disease of bone is a treatable chronic disease that results in enlarged and misshapen bones in one or more areas of the skeleton. Healthy bone goes through a continuous renewal process in which old bone is broken down by cells called osteoclasts and new bone is formed by cells called osteoblasts. In Pagets disease, these two cells do not interact normally. Instead, bone breakdown and formation are excessive and produce bone that is enlarged and has a weaker structure. Some of the symptoms and complications that can result from Pagets disease include bone pain, osteoarthritis, misshapen bone, and broken bones. Scientists and doctors do not fully understand what causes Pagets disease of bone. How Does Genetics Relate to Pagets Disease of Bone? Genetics is the branch of biology that deals with heredity and variations in people and other living things. It is an exciting area of research for Pagets disease. Recent studies suggest that genetics plays a role in at least some cases of Pagets disease. For example, Pagets disease can run in families. When this happens, it is referred to as familial or hereditary Pagets disease. However, the majority of people with Pagets disease do not have any affected relatives and do not appear to have familial Pagets disease. When there is no family history, the disease is referred to as sporadic. National Institutes of Health Osteoporosis and Related Bone Diseases National Resource Center 2 AMS Circle Bethesda, MD 20892-3676 Tel: (800) 624-BONE or (202) 223-0344 Fax: (202) 293-2356 TTY: (202) 466-4315 Internet: www.niams.nih.gov/bone E-mail: NIAMSBONEINFO@ mail.nih.gov The NIH Osteoporosis and Related Bone Diseases National Resource Center is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases with contributions from the National Institute of Child Health and Human Development, National ...

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