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Diagnosis and Treatment of Paget's Disease of Bone -- American Family ...

Source: www.aafp.org
Topic: Paget's disease of bone
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Sort Desciption: Paget's disease of bone (also known as osteitis deformans) is a nonmalignant ... in a patient with bone scans suggestive of Paget's disease. BIOCHEMICAL MARKERS ...

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Paget's disease of bone (also known as osteitis deformans) is a nonmalignant disease involving accelerated bone resorption followed by deposition of dense, chaotic, and ineffectively mineralized bone matrix. The origin of the disease is unknown, and it is frequently asymptomatic; however, the patient may present with symptoms depending on the bones involved. The most common symptom is pain in the affected bone; neurologic, hearing, vision, cardiac, and oncologic complications are possible. Diagnosis is primarily made by radiographs. Bisphosphonates are the most common treatment. (Am Fam Physician 2002;65:2069-72. Aside from osteoporosis, Paget's disease is the most common bone disorder. Paget's disease is equally prevalent in men and women, with increased incidence in persons older than 50 years. It affects approximately 3 percent of persons in the United States, and as many as 10 percent of persons older than 80 years.

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