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Anti-phospholipid Antibodies and Thrombosis

Source: www.informatik.uni-freiburg.de
Topic: Thrombosis
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Sort Desciption: The paper gives some preliminary comments on the submissions to Discovery Challenge on Thrombosis data. 1 What is APS ? Collagen diseases were defined by Dr Klemperer, as ...

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The paper gives some preliminary comments on the submissions to Discovery Challenge on Thrombosis data. 1 What is APS ? Collagen diseases were defined by Dr Klemperer, as characterized clinically by rheumatism features, or pathologically belonged to connective tissue diseases. They were also classified autoimmune diseases because of immunological abnormalities. Collagen disease is not a sole disease, but one category like pulmonary disease which is composed of several diseases. Anti-phospholipid syndrome (APS) is probably the newest one which is categorized as a collagen disease. This disease causes thrombosis (vessel stasis by blood clots), such as myocardial infarction or stroke. However, even if patients have this antibody in their serum, not all patients show thrombosis. Therefore we would like to know the mechanism of how the thrombosis occurs in these patients. Finally it is very important to predict for whom and when thrombosis may occur. In general, anti-cardiolipin antibody (aCL) (one kind and representative antibody of anti-phospholipid antibodies) has a significant relation to thrombosis. Especially IgG type aCL (aCL IgG) is believed to be strong indicator of thrombosis. In addition, other antibodies such as aCL IgM, aCL IgA have also shown some relation to thrombosis. LAC, PT and APTT are methods to detect the abnormality of blood coagulation, especially significant in these patients. Thrombocytopenia is often accompanied with APS, however the mechanism is unknown. In fact, the phenomenon is not clear yet, and the discrepancy between the test results often confuse clinicians. 2 Data mining technique on APS 2.1 Estimation concept Thus from current medical knowledge, we can estimate a data mining technique works well or not by observing if it can point out ...

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