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Alpha Thalassemia

Source: www.cooleysanemia.org
Topic: Thalassemia
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Sort Desciption: Physicians often mistake alpha thalassemia trait for iron deficiency anemia and incorrectly prescribe iron supplements that have no effect on the anemia. ...

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Physicians often mistake alpha thalassemia trait for iron deficiency anemia and incorrectly prescribe iron supplements that have no effect on the anemia. Normal alpha globin genes found on chromosome 16 People who do not produce enough alpha globin protein chains have alpha thalassemia. It is commonly found in Africa, the Middle East, India, Southeast Asia, southern China, and occasionally the Mediterranean region. Alpha globin is made by four genes, two on each strand of chromosome 16. Individuals who have one or two abnormal alpha globin genes have alpha thalassemia trait. An individual with one abnormal alpha globin gene is said to be a silent carrier of alpha thalassemia. This condition, in which one of the four alpha globin genes is missing or defective, generally causes no health problems because the lack of alpha globin protein is so small that there is no anemia. It is called silent carrier because of how difficult it is to detect. Silent carrier state is diagnosed by deduction when an apparently normal individual has a child with hemoglobin H disease or alpha thalassemia minor. It can also be diagnosed by special DNA testing. Alpha Thalassemia Trait. In this condition, in which two of the four alpha globin genes are missing or defective, the lack of alpha globin protein is somewhat greater. Both abnormal alpha globin genes may be on the same chromosome (cis position) or one may be on each chromosome in the pair (trans position). Physicians often mistake alpha thalassemia trait for iron deficiency anemia and incorrectly prescribe iron supplements that have no effect on the anemia. Patients with this condition have smaller red blood cells and a mild anemia, although they do not experience symptoms. An individual with two abnormal alpha globin genes is said to have alpha thalassemia trait. The two abnormal genes can be on the same chromosome or on each chromosome in the pair. alpha thalassemia trait If both parents ...

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