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The Teenager with Sickle Cell


image: The Teenager with Sickle Cell

Source: www.sicklecell.md
Topic: Sickle Cell Disease
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Sort Desciption: a lady wrote to me: I have three children. Both my husband and I are AS. Our daughter is SS, her younger brother is AA, and our last born is AS. Is there no cure for Sickle Cell Anemia? I shall come to this question after dealing with an Ache/Ache teenager ...

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a lady wrote to me: I have three children. Both my husband and I are AS. Our daughter is SS, her younger brother is AA, and our last born is AS. Is there no cure for Sickle Cell Anaemia? I shall come to this question after dealing with an Ache/Ache teenager, but first let us see whether you got full marks answering the questions I set you in the test in New African March issue. Q 1: Can an AS Trait suffer from hand-foot syndrome? Answer: No Sickle Cell traits do not have sickle cell crisis. The hand-foot syndrome is a manifestation of sickle cell crisis. Sickle Cell Traits have run at the Olympic Games at Mexico City, 80 00 feet high, where t he oxygen concentration is thinner than at ground level, and beaten the whole world. So stories about sickle cell traits dying suddenly when exercising on a mountain at 4,000 ft are based on ignorance. (See my website www.sicklecell.md where the subject has been treated in more detail). The proportion of Haemoglobin S in the Sickle Cell Trait (AS) is less than 39.7%, and can be as low as 20% not enough at all to change the shape of the cell in the body from round to sickle shape. We shall devote a whole article later to the Sickle Cell Trait. But if someone who was thought to be AS had a real sickle cell crisis from fever, exercise, pneumonia, or flying, then the blood should be checked again and the S and A fractions by haemoglobin electrophoresis quantified. If S% is greater than A%, then the smaller A has come from a beta-thalassaemia gene, and the patient has sickle-cell beta-Thalassaemia (Ache/Ache), not sickle cell trait. The small A does not come from a normal Haemoglobin A gene (Norm) but from a beta-Thalassaemia gene (Ache). Read that again. Have you got the point? A true Sickle Cell Trait child (Haemoglobin A greater than Haemoglobin S ie Norm/Ache) cannot have the hand-foot syndrome, ...

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