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Sickle Cell Anemia & the Hemoglobin Gene Using Bioinformatics in Medicine

Source: www.jdenuno.com
Topic: Sickle Cell Disease
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Sort Desciption: Sickle Cell Anemia Most common genetic disease in US high incidence in African-Americans affects red blood cells potentially lethal 2004-2005 AP Biology Symptoms Anemia jaundice, fatigue, paleness, shortness of breath ...

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Sickle Cell Anemia Most common genetic disease in US high incidence in African-Americans affects red blood cells potentially lethal 2004-2005 AP Biology Symptoms Anemia jaundice, fatigue, paleness, shortness of breath Hypoxia (low oxygen) & capillary damage severe pain in organs & joints retinal damage (blindness) Delayed growth delayed puberty, stunted growth Infections more susceptible depressed immune death from bacterial infections Stroke blocked small blood vessels in brain primarily in children 2004-2005 AP Biology Sickle cell hemoglobin mutant hemoglobin (Hb S) 2004-2005 AP Biology 2004-2005 AP Biology Cell biology Hb S molecules stick together form fibers under low blood oxygen levels distortion of cells from normal round to sickle shape 2004-2005 AP Biology Sickle cell mutation Hb S changes 6 th amino acid of hemoglobin chain normal glutamic acid valine Recessive allele heterozygote Hb AS, normal, but carrier homozygote recessive Hb SS, sickle cell disease 2 sickle cell carriers mate each child has 1/4 chance of having the disease Genetics Hb A Hb S Hb A Hb S HbAA HbAS HbSS HbAS 2004-2005 AP Biology Prevalence in U.S. Carriers 2 million Americans carry sickle cell trait 1 in 14 African-Americans Disease 72,000 Americans have disease 1 in every 700 African-American babies born in U.S. has sickle cell disease 2004-2005 AP Biology The Malaria Connection Sickle cell disease is surprisingly common for a potentially lethal genetic disease Heterozygote advantage heterozygotes are tolerant of malaria infection & do not suffer symptoms of sickle cell disease 2004-2005 AP Biology Malaria 2004-2005 AP Biology Prevalence of Malaria Prevalence of Sickle Cell Anemia sickle cell movie 2004-2005 AP Biology Public health Many carriers of this mutant allele are ...

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