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The Clark Family Story: Tracing the Cause of Hemophilia

Source: www.cdc.gov
Topic: Hemophilia
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Sort Desciption: by Trish Strohfeldt. This lesson is for a senior level biology course and emphasizes the relationship between DNA sequences, mutations in DNA and the change in the resulting protein structure and function.

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by Trish Strohfeldt West Bend East High School, West Bend, Wisconsin In collaboration with the Centers for Disease Control and Preventions Nicole Dowling and Stacy League This lesson is for a senior level biology course and emphasizes the relationship between DNA sequences, mutations in DNA and the change in the resulting protein structure and function. Hemophilia A will be used as a real life example of how a mutation in DNA results in a change in a proteins structure and resulting ability to function. In order to complete these activities, the students should have prior knowledge in DNA structure and mutations, protein synthesis, Mendelian genetics and sex-linked traits. Disclaimer: The findings and conclusions in this report are those of the author(s) and do not necessarily represent the views of the Centers for Disease Control and Prevention. The Clark Family Story: Tracing the Cause of Hemophilia by Trish Strohfeldt West Bend East High School West Bend, Wisconsin Summary This lesson is for a senior level biology course and emphasizes the relationship between DNA sequences, mutations in DNA and the change in the resulting protein structure and function. Hemophilia A will be used as a real life example of how a mutation in DNA results in a change in a proteins structure and resulting ability to function. In order to complete these activities, the students should have prior knowledge in DNA structure and mutations, protein synthesis, Mendelian genetics and sex-linked traits. Learning Outcomes The student will be able to relate a DNA sequences to the resulting protein structure in the factor VIII gene. The student will be able to demonstrate the use of restriction enzymes in the identification of a specific DNA sequence and explain how this can be used to diagnosis someone has having the hemophilia factor VIII mutation. The student will be able to demons ...

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