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Hemophilia: Basic Questions & Answers

Source: www.caremark.com
Topic: Hemophilia
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Sort Desciption: What is hemophilia? What is clotting factor? How does a person get hemophilia? ...

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Q. What is hemophilia? A. Hemophilia is a rare type of bleeding disorder that occurs when there is a deficiency or absence of a particular protein (clotting factor) needed for blood to clot. As a result, a person with hemophilia will experience longer bleeding after an injury because the clot formed is not strong enough to stop the bleeding. A person with hemophilia will not bleed any faster than a person without hemophilia, but he or she will bleed slower and longer. This type of bleeding disorder is inherited and occurs almost exclusively in males. Q. What is clotting factor? What does it do? A. Clotting factor is a series of blood proteins that go to work after theres an injury that damages blood vessels. When a blood vessel is torn, it tightens to reduce the flow of blood. Tiny cells in the blood called platelets stick together at the injury site to form a platelet plug, and thread-like strands called fibrin bind the platelets together and form a fibrin net. The fibrin net entraps the plug, which has developed into a blood clot through a series of interactions among certain proteins in the blood (clotting factor). There are thirteen clotting factors and they all work in sequence to help form a clot. The type of clotting factor that is missing determines what kind of hemophilia you have. The two most common types are hemophilia A and hemophilia B. In hemophilia A, the missing clotting factor is factor VIII. Hemophilia A is sometimes referred to as classical hemophilia. In hemophilia B, the missing clotting factor is factor IX. Hemophilia B is sometimes referred to as Christmas disease. Q. How does a person get hemophilia? A. Hemophilia is an inherited disease, meaning that a gene responsible for causing hemophilia is passed from parent to offspring. In the United States, about one or two in every 10,000 male infants is born with it. Approximately 80 percent have hemophilia A, a ...

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