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Screening for Hemochromatosis: Recommendation Statement

Source: www.ahrq.gov
Topic: Hemochromatosis
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Sort Desciption: U.S. Preventive Services Task Force* This statement summarizes the U.S. Preventive Services Task Force (USPSTF) recommendation on screening for hemochromatosis and the supporting scientific evidence. ...

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U.S. Preventive Services Task Force* This statement summarizes the U.S. Preventive Services Task Force (USPSTF) recommendation on screening for hemochromatosis and the supporting scientific evidence. The complete information on which this statement is based, including evidence tables and references, is available in the accompanying article in this issue and on the USPSTF Web site (www.preventiveservices.ahrq.gov). The USPSTF is redesigning its recommendation statement in response to feedback from primary care clinicians. The USPSTF plans to release, later in 2006, a new, updated recommendation statement that is easier to read and incorporates advances in USPSTF methods. The recommendation statement in this paper is an interim version that combines existing language and elements with a new format. Although the definitions of grades remain the same, other elements have been revised. Ann Intern Med. 2006;145:204-208. www.annals.org Individuals who wish to cite this recommendation statement should use the following format: U.S. Preventive Services Task Force. Screening for hemochromatosis: recommendation statement. Ann Intern Med. 2006;145:204-208. * For a list of the members of the U.S. Preventive Services Task Force, see the Appendix. S UMMARY OF THE R ECOMMENDATION The U.S. Preventive Services Task Force (USPSTF) recommends against routine genetic screening for hereditary hemochromatosis in the asymptomatic general population. This is a grade D recommendation. (See Appendix Table 1 for a description of the USPSTF classication of recommendations.) R ATIONALE Importance: There is fair evidence that disease due to hereditary hemochromatosis is rare in the general population. (See Appendix Table 2 for a description of the USPSTF classication of levels of evidence.) Detection: The USPSTF found fair evidence that a low proportion of individuals with a high-risk ...

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