Hereditary Hemochromatosis
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Topic: Hemochromatosis
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Sort Desciption: Public Health and Genetics Information Series Hereditary Hemochromatosis Why is Hereditary Hemochromatosis (HH) an emerging public health issue? As a common genetic disorder with simple ...
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Public Health and Genetics Information Series Hereditary Hemochromatosis Why is Hereditary Hemochromatosis (HH) an emerging public health issue? As a common genetic disorder with simple, effective treatment, hemochromatosis offers a model for other genetically influenced chronic diseases that some day may have interventions to improve prognosis. Population screening for hemochromatosis using the transferrin saturation test has been advocated by some experts to permit the initiation of therapeutic phlebotomy (the incision of a vein for the purpose of removing blood from the body) before the onset of some health complications. However, this view is not universal (see report of the working group Iron overload, public health, and genetics. Ann Int Med 129:921-96). Hemochromatosis is one of the most common known genetic disorders in the United States Caucasian population and is a treatable condition. Approximately 1 in 200-400 people in the United States has hemochromatosis. Between one in eight and one in every ten people in the general population have the gene . Despite the high prevalence of hemochromatosis, most cases go undiagnosed. The symptoms are often confused with other conditions. This enforces the need for increased knowledge about the disorder. Routine screening for adults appears to be cost effective and the condition is treatable. Suggested reading: Cogswell ME, McDonnell SM, Khoury MJ, Franks AL, Burke W, Brittenham G (1998) Iron overload, public health, and genetics: evaluating the evidence for hemochromatosis screening. Ann Intern Med 129:971-9 Medline What is HH? Hemochromatosis (He-mo-chro-ma-toe-sis) is commonly known as iron overload disease. It is a treatable disorder where excessive amounts of iron are absorbed and subsequently accumulates in body tissues. The accumulation of iron damages body organs, especially the pancreas, liver and heart. Excess iron may be removed thereby preventing the progression of HH. ...
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