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Hemochromatosis Diagnosis/Testing

Source: www.cdnhemochromatosis.ca
Topic: Hemochromatosis
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Sort Desciption: Canadian Hemochromatosis Society Suite ... Hemochromatosis Diagnosis / Testing Transferrin Saturation and Serum Ferritin Tests Currently, tests for hemochromatosis are not part of a general medical checkup. ...

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Canadian Hemochromatosis Society Suite 272 7000 Minoru Blvd Richmond, BC Canada V6Y 3Z5 Toll-Free (Canada): 1-877-BAD-IRON (1-877-223-4766) Tel: (604) 279-7135 Fax: (604) 279-7138 E-mail: office@ toomuchiron.ca Web: www. toomuchiron.ca Rev. 05-Dec-2006 1 / 2 Hemochromatosis Diagnosis / Testing Transferrin Saturation and Serum Ferritin Tests Currently, tests for hemochromatosis are not part of a general medical checkup. They must be specifically ordered on a blood lab requisition form. A doctor can order an iron series profile and, depending on the lab, may include serum iron, ferritin, transferrin, and transferrin saturation or total iron binding capacity. Of particular importance in this profile is serum ferritin (SF) and transferrin saturation (TS). These tests should ideally be performed in the morning after the patient has fasted overnight for a more accurate reading. Serum ferritin and transferrin saturation measurements reflect how much iron is in the body and how much is being transported and stored. Biochemical Blood Screening Tests Serum Ferritin (SF) A normal serum ferritin result varies with gender and age. An abnormally high ferritin will be highlighted on the lab test result as out of range. Ferritin is a non-specific test and can be elevated for reasons other than hemochromatosis. Subsequent tests may be necessary to see if elevations continue over time. A level of more than 200 ng/ml for women and 300 ng/ml for men is considered out of range, but it is rare for organ damage to occur with ferritin levels below 1000 ng/ml. Transferrin Saturation (TS) A normal result is typically 25-40% saturation. Anything greater than 45% saturation requires further investigation. Transferrin saturation is more specific to hemochromatosis but is still considered a screening test and on its own does not confirm hemochromatosis. If both serum ferritin and transferrin saturation come back abnormally high, or even high normal, these scr ...

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