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Side Effect Management: Hemolytic Anemia

Source: www.hcvadvocate.org
Topic: Anemia
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Sort Desciption: hcspFACTsheet Hepatitis C Support Project www.hcvadvocate.org a series of fact sheets written by experts in the eld of liver disease ...

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Side Effect Management: Hemolytic Anemia hcspFACTsheet Hepatitis C Support Project www.hcvadvocate.org a series of fact sheets written by experts in the eld of liver disease Side Effect Management: Hemolytic Anemia Red blood cells carry oxygen to body tissues, producing fuel that the body needs to stay healthy. The normal average life span of a red blood cell is about 120 days; after red blood cells have worn out, the spleen removes them from circulation. Hemolytic anemia refers to a condition in which red blood cells are destroyed faster than the body can make enough new ones to replace them. Treatment for hepatitis Cin particular ribavirincan cause hemolytic anemia. It is estimated that up to 22% of patients taking pegylated interferon plus ribavirin experience hemolytic anemia. The likelihood of anemia is related to the dose of ribavirin taken. Symptoms The most common symptoms of anemia include shortness of breath, fatigue, pale skin color, chills, rapid heart rate, depression, and reduced quality of life. If left unchecked, hemolytic anemia can lead to jaundice, dark urine, and an enlarged spleen. In severe cases, cardiac arrest (heart attack) can occur. This is why it is important for people considering pegylated interferon plus ribavirin therapy to have a physical exam to rule out any potential heart problems before starting HCV treatment. Diagnosis A simple blood test called a complete blood count (CBC) measures various components of blood including red cells, white cells, and platelets. The portion of the blood test that measures red blood cells and their oxygen-carrying capacity,hemoglobin and hematocrit,are used to diagnose anemia. Normal Ranges Male Ranges Female Ranges Hemoglobin 14.0-18.0 g/dL 12.0-16.0 g/dL Hematocrit 42.0-52.0 % 37.0-48.0 % A low hemoglobin or hematocrit measurement indicates anemia. Treatment There are two approaches for treating hemolytic anemia: ribavirin dose reduction and use of a growth factor hormone (erythropoietin) to promo ...

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