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Drug provocation testing in the diagnosis of drug hypersensitivity reactions

Source: www.eaaci.net
Topic: Drugs
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Sort Desciption: interest group on drug hypersensitivity with the following additional ... Drug hypersensitivity reactions comprising both allergic ...

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Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations A drug provocation test (DPT) is the controlled administration of a drug in order to diagnose drug hypersensitivity reactions. DPTs are performed under medical surveillance, whether this drug is an alternative compound, or structurally/pharmacologically related, or the suspected drug itself. DPT is sometimes termed controlled challenge or reexposure (1), drug challenge (2), graded (2) or incremental challenge (3), test dosing (2), W. Aberer 1 , A. Bircher 2 , A. Romano 3 , M. Blanca 4 , P. Campi 5 , J. Fernandez 6 , K. Brockow 7 , W. J. Pichler 8 , P. Demoly 9 for ENDA * , and the EAACI interest group on drug hypersensitivity 1 Department of Environmental Dermatology, University of Graz, Graz, Austria; 2 Department of Dermatology, Basle, Switzerland; 3 Allergy Service, CatholicUniversity of Rome, Italy; 4 Allergy Service, University La Paz, Madrid, Spain; 5 Clinicfor Allergy and Immunology, Florence, Italy; 6 Allergy Section, Dept. Clin. Med., UMH, Elche, Spain; 7 Klinik und Poliklinik f r Dermatologie und Allergologie, Muenchen, Germany; 8 Clinicfor Rheumatology and Clinical Immunology/Allergology, Inselspital, Bern, Switzerland; 9 Maladies Respiratoires-INSERM U454, H pital Arnaud de Villeneuve, Montpellier, France Werner Aberer, Department of Dermatology, University of Graz, Auenbruggerplatz 8, A-8036 Graz, Austria Tel.: +43-316-385 3925 Fax: +43-316-385 3782 E-mail: werner.aberer@uni-graz.at Pascal Demoly, ENDA Secretary, Maladies Respiratoires INSERM U454, H pital Arnaud de Villeneuve, CHU de Montpellier, 34295 Montpellier cedex 5, France Tel: +33-467336127 Fax: +33-467042708 E-mail: demoly@montp.inserm.fr Werner Pichler, ENDA President, Clinic for Rheumatology and Clinical Immunology/ Allergology, Inselspital, 3010 Bern, Switzerland Tel.: +41-316 ...

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