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Screening for Allergic Disorders

Source: www.stanfordlab.com
Topic: Chemicals
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Sort Desciption: The traditional approach has been in vivo skin testing. Small amounts of allergen solutions are introduced into the patient s skin (usually the forearm). ...

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The traditional approach has been in vivo skin testing. Small amounts of allergen solutions are introduced into the patient s skin (usually the forearm). A wheal-and-flare reaction (edema surrounded by vascular congestion) due to the immediate release of histamine is indicative of the presence of specific IgE on the patient s mast cells. Skin testing requires significant expertise (both to perform and interpret) and may be problematic when the patient is taking antihistamines, has extensive skin disease, or is at risk of serious reactions to the allergen. Consequently, in vitro methods that correlate with the results of skin testing (and that could be performed on serum specimens) have been eagerly pursued. All of the common symptoms seen in allergic disorders may have other causes. Rhinitis, sinusitis and upper airway problems (including asthma) may be due to infections or irritants. Urticaria and eczema may be caused by a variety of skin diseases. A history of intermittent symptoms (especially if related to seasonal change) and specific triggers help point to allergy. But the physician needs to know whether allergy is really behind the patient s symptoms before beginning potentially expensive therapies that may not work if it is not. FEATURE ARTICLE HIGHLIGHTS>> Screening for Allergic Disorders James Faix, M.D. Director of Chemistry · Allergy symptoms & other etiologies · Stanford in vitro IgE testing · Future Developments: New Multiplex Immunoassay Approach · In vitro IgE result evaluation flow chart Laboratory Update: Stanford Clinical Laboratory New Web Site www.stanfordlab.com Q&A: Critical / Panic Values Michael Petzar, M.D. Pathology Department James Faix, M.D. Director of Clinical Chemistry and Immunology at Stanford Clinical Laboratory and Associate Professor of Pathology at Stanford University School of Medicine. Dr. Faix directs the allergy, automated chemistry, blood gas, endocrinology, immunology, ...

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