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Laboratory Animal Allergens

Source: www.bu.edu
Topic: Animals
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Sort Desciption: most common causes of laboratory animal allergy are rats ... Management of allergies to animals. Allergy Proc 13:289-292. Flower DR. 1996. ...

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Laboratory Animal Allergens 12 ILAR Journal Abstract Allergic sensitivity to laboratory animals can pose significant occupational hazard to anyone with regular animal contact. Reactions to mice and rats are most common, although all furred animals produce allergens that can lead to sensitization and disease. Most of the relevant allergens of laboratory animals have been defined and characterized, which has revealed that these allergens are typically small, acidic glycoproteins and that many of them are members of a superfamily of extracellular proteins called lipocalins. In addition to understanding their molecular characteristics, the identification of these allergens has also made it possible to measure their distribution in laboratory environments and to relate exposure levels to sensitization and symptoms. These studies have shown that the major laboratory animal allergens are carried on small particles that are both capable of remaining airborne for extended periods and penetrating into the lower airways of exposed workers. The seadvances in the understanding of these important occupational allergens will allow for the development of better methods of diagnosis and avoidance for affected workers and others who may be at risk for future difficulties. Key Words: allergen; animal allergens; animal allergy; laboratory animal allergy; mouse; rat; rodent Introduction At least 90,000 workers in the United States have direct contact with animals in research or industrial facilities(Eggleston and Wood 1992; Newill et al. 1986). Workers who are in regular contact with furred animals often develop sensitivity to these animals. This sensitivity accounts for the high prevalence of laboratory animal allergy in animal workers, estimated from multiple independent studies to be approximately 21% (Aoyama et al. 1992; Bland et al. 1986;Hunsaker and Fosse 1990; Slovak and Hill 1981). This high prevalence rate has major medical and economic implications. When employees develop laboratory ...

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